Keywords

• INCB024360
• 914471-09-3
• Pharmaceutical Chemicals

Quick Details

• ProName: high quality INCB024360
• CasNo: 914471-09-3
• Appearance: White powder
• Application: lab research
• DeliveryTime: 3days
• PackAge: 10g/pack,100g/pack,1kg/pack
• Port: Shanghai port
• ProductionCapacity: 10000 Kilogram/Year
• Purity: 99%min
• Storage: storage in a dry, ventilated place und...
• Transportation: BY EMS,FEDEX,AIR
• LimitNum: 1 Gram
• Valid Period: 2years
• Batch: 20140302

Superiority

1,In No Less five years exporting experience.

2.Lower Price with higher quality

3,Free sample

4,We are sincerely responsible for the "product quality" and "After Service"

Details

INCB024360 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may inhibit the growth of IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and DCs

only for lab resarch