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Ms.NancyCAS NO.7177-48-2
99%(1-1000)Gram
7177-48-2 superior manufacturer Ampicillin factory sells superior manufacturer
Ampicillin Trihydrate is the trihydrate form of ampicillin, a broad-spectrum semisynthetic derivative of aminopenicillin. Ampicillin trihydrate inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall.
Ampicillin, a penicillin-like antibiotic, is enzymatic synthesized from 6-APA catalyzed by penicillin acylase. Ampicillin is the first of a number of so-called broad spectrum penicillins. That amino group helps the drug penetrate the outer membrane of Gram-negative bacteria. Thus, ampicillin has activity against not only Gram-positive bacteria such as Staphylococci and Streptococci but also Gram-negative bacteria such as H. influenzae, coliforms and Proteus species. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Its spectrum of activity is enhanced by co-administration of sulbactam, a drug that inhibits beta lactamase an enzyme produced by bacteria to inactivate ampicillin. Ampicillin is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for ampicillin resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.
| Alternate Name | D-(−)-α-Aminobenzylpenicillin, trihydrate |
|---|---|
| Appearance | White solid |
| CAS # | 7177-48-2 |
| Molecular Formula | C??H??N?O?S. 3H2O |
| Molecular Weight | 403.45 |
| Solubility | H?O (~10 mg/ml) or 1 N HCl (50 mg/ml) |
| SMILES | CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)C.O.O.O |
| InChi | InChI=1S/C16H19N3O4S.3H2O/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);3*1H2/t9-,10-,11+,14-;;;/m1.../s1 |
| InChi Key | RXDALBZNGVATNY-CWLIKTDRSA-N |
| PubChem CID | 23565 |
| MDL Number | MFCD00005175 |
| Handling | Protect from air and moisture |
| Storage Conditions | + 4°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |