Shanghai Upbio Tech Co.,Ltd
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Ms.NancyCAS NO.69-65-8
99%(1-1000)Kilogram
69-65-8 Hot Sale Good Supplier In China D-Mannitol reasonable price
A sugar alcohol. More closely related to carbohydrates than to other polyhydric alcohols [Noller]. Flammable and/or toxic gases are generated by the combination with alkali metals, nitrides, strong reducing agents and strong oxidizing agents.
Mannitol is a sugar alcohol occurring widely in plants and they are exudates, for example, in olive and plane trees (Collins, 2006). It is produced commercially by the catalytic hydrogenation of fructose (Zelin, 2019). Mannitol is used extensively in food and pharmaceutical industries because of its unique functional properties. It is about 50% as sweet as sucrose and has a desirable cooling effect often used to mask bitter tastes. Mannitol is non-cariogenic and has a low caloric content. Mannitol is an osmotic diuretic that is metabolically inert in humans and is used for: the promotion of diuresis before irreversible renal failure becomes established, the promotion of urinary excretion of toxic substances, as an Antiglaucoma agent, and as a renal function diagnostic aid (O’Neil, 2013). Additonally, in 2020, mannitol was approved by the FDA as add-on maintenance therapy for the control of pulmonary symptoms associated with cystic fibrosis in adult patients
D(-)Mannitol is a sugar alcohol that can be used as an inert osmotic control substance. The uptake and phosphorylation of d-mannitol is catalyzed by the mannitol-specific phosphoenolpyruvate-dependent phosphotransferase systems (PTS). Mannitol can interact with neutrophils and monocytes. Experiments have shown that it is able to decrease neutrophil apoptosis in vitro. The compound has been used in studies as a stimulator of cecal microbial growth and cellulolytic activity in rabbits. It has been observed that mannitol can lower the fat digestibility and body fat accumulation in both normal and cecectomized rats, as well as upregulate monocyte HLA-DR, monocyte and neutrophil CD11b. Studies show that the mannitol operon is repressed by the transcription factor, mannitol operon repressor (MtlR) in Escherichia coli.