Business Type:Lab/Research institutions
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Country: China (Mainland)
Business Type:Lab/Research institutions
CAS NO.503612-47-3
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Company Introduction:
Onchem (China) Co.,Ltd is a comprehensive manufacturer and an international distribution of chemicals throughout the world. Specialized in APIs, chemical intermediates, herbal extract and pharmaceutical raw materials.
ProName:Apixaban
IUPAC:1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[5,4-c]pyridine-3-carboxamide
Bioavailability:ca. 50%
Half-life:9–14 h
Excretion:75% biliary, 25% renally
CAS number:503612-47-3
ATC code:B01A
PubChem:CID 10182969
DrugBank:DB07828
ChemSpider:8358471
UNII:3Z9Y7UWC1J
KEGG:D03213
ChEMBL:CHEMBL231779
Formula:C25H25N5O4
Mol. mass:459.497 g/mol
InChI:InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
Product information:
Apixaban (INN, trade name Eliquis) is an anticoagulant for the prevention of venous thromboembolism and the prevention of stroke in atrial fibrillation.
Apixaban is a factor Xa inhibitor (anticoagulant) indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. A systematic review of new anticoagulants states the treatment benefits of apixaban and other new anticoagulants compared with warfarin are small and vary depending on the control achieved by warfarin treatment. Patients already taking warfarin with excellent international normalized ratio (INR) control may have little to gain by switching to new oral anticoagulants in atrial fibrillation.
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