Keywords

• 103-90-2 Hot Sale
• Good Supplier In China 103-90-2
• Paracetamol reasonable price

Quick Details

• ProName: 103-90-2 Hot Sale Good Supplier In Ch...
• CasNo: 103-90-2
• Molecular Formula: C8H9NO2
• Appearance: White powder
• Application: used in pharmaceuticla
• DeliveryTime: 3-15days
• PackAge: 1kg/pack,25kg/drum
• Port: Shanghai Port
• ProductionCapacity: 10000 Kilogram/Year
• Purity: 99%min
• Storage: Storage in a dry, ventilated place und...
• Transportation: by EMS,FEDEX,UPS
• LimitNum: 1 Kilogram
• Related Substances: qualified
• Residue on Ignition: qualified
• Heavy Metal: qualified
• Valid Period: 2years
• Batch: 20210609

Superiority

103-90-2  Hot Sale Good Supplier In China Paracetamol reasonable price

Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

Acetaminophen is analgesic and antipyretic drug. It is a pain reliever commonly used to treat headache, muscle aches, arthritis, and other acute or chronic painful conditions.This compound is a contaminant of emerging concern (CECs).

acetaminophen elicites a 4.4-fold selectivity toward COX-2 inhibition (IC₅₀ 113.7 μM for COX-1; IC₅₀ 25.8 μM for COX-2). Following oral administration of the drug, maximal ex vivo inhibitions are 56% (COX-1) and 83% (COX-2). Acetaminophen plasma concentrations remaine above the in vitro IC₅₀ for COX-2 for at least 5 h postadministration. Ex vivo IC₅₀ values (COX-1: 105.2 μM; COX-2: 26.3 μM) of acetaminophen compared favorably with its in vitro IC₅₀ values. In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors. However, a >95% COX-1 blockade relevant for suppression of platelet function is not achieved. MTT assay shows that Acetaminophen (APAP) in a dose of 50 mM significantly (p<0.001) reduces cell viability to 61.5±6.65%. Interestingly, the significant (p<0.01) increase in cell viability to 79.7±2.47% is observed in the Acetaminophen/HV110 co-treated cells, compared to Acetaminophen treated cells

Details

• Product name

  Acetaminophen, COX-3 inhibitor

• Description

  Selective COX-3 inhibitor

• Alternative names

  • Paracetamol

• Biological description

  Selective COX-3 inhibitor (IC₅₀ = 460 μM). NSAID with widely used analgesic and antipyretic effects. Blood-brain barrier permeable.

• Purity

  > 98%

• CAS Number

  103-90-2

• Chemical structure