Keywords

• 103-90-2 Acetaminophen
• Acetaminophen Intermediates
• for sale 103-90-2 Paracetamol

Quick Details

• ProName: 103-90-2 Acetaminophen Acetaminophen ...
• CasNo: 103-90-2
• Molecular Formula: C8H9NO2
• Appearance: White powder
• Application: used in pharmaceuticla
• DeliveryTime: 3-15days
• PackAge: 1kg/pack,25kg/drum
• Port: Shanghai Port
• ProductionCapacity: 10000 Kilogram/Year
• Purity: 99%min
• Storage: Storage in a dry, ventilated place und...
• Transportation: by EMS,FEDEX,UPS
• LimitNum: 1 Kilogram
• Related Substances: qualified
• Residue on Ignition: qualified
• Heavy Metal: qualified
• Valid Period: 2years
• Batch: 20210609

Superiority

Acetaminophen Acetaminophen Intermediates for sale 103-90-2 Paracetamol

Acetaminophen is an analgesic and antipyretic compound.Unlike many NSAIDs, which inhibit both COX-1 and COX-2, early studies suggested that acetaminophen is a poor inhibitor of both isoforms.However, it does inhibit COX-2 by 83% and COX-1 by 56% in human blood ex vivo, albeit at a high 1,000 mg dose, with IC₅₀ values of 25.8 and 113.7 µM, respectively. Acetaminophen is enzymatically and non-enzymatically converted to several reactive metabolites that contribute to adverse or indirect effects, including liver injury. At toxic doses, the acetaminophen metabolite N-acetyl-4-benzoquinone imine depletes glutathione reserves in the liver, leading to an accumulation of NAPQI and subsequent hepatocyte necrosis. Acetaminophen decreases glutathione levels and reduces glutathione peroxidase activity in mice when administered at a dose of 250 mg/kg and induces ferroptotic cell death in primary mouse hepatocytes, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 Acetaminophen has analgesic and antipyretic properties in animal models.

Details