Keywords

• low price 518-34-3
• 518-34-3 D-Tetrandrine On Sale
• Tetrandrine in bulk supply

Quick Details

• ProName: low price 518-34-3 518-34-3 D-Tetrandr...
• CasNo: 518-34-3
• Molecular Formula: C9H11NO2
• Appearance: white,Crystalline Powder or colorles p...
• Application: Used in Pharmaceutical,health food
• DeliveryTime: 3days
• PackAge: 10g/pack ,100g/pack,1kg/pack (aluminum...
• Port: Shanghai port
• ProductionCapacity: 10000 Kilogram/Year
• Purity: 99%min
• Storage: Storage in a dry, ventilated place und...
• Transportation: By EMS,FEDEX,AIR
• LimitNum: 1 Kilogram
• Related Substances: ok
• Residue on Ignition: ok
• Heavy Metal: qualified
• Valid Period: 2years
• Batch: 20150409

Superiority

low price 518-34-3 D-Tetrandrine On Sale Tetrandrine in bulk supply

Tetrandrine is a bis-benzylisoquinoline alkaloid that has been found in R. stephania roots and has diverse biological activities. It induces autophagy in HeLa, MCF-7, and human foreskin fibroblast (HFF) cells when used at a concentration of 5 µM, an effect that can be reversed by the autophagy inhibitor 3-methyladenine Tetrandrine inhibits PAF-, thrombin-, collagen-, ADP-, or epinephrine-induced aggregation of isolated human platelets. Priming of mesenchymal stem cells (MSCs) with tetrandrine (5 and 10 µM) reduces TNF-α secretion by RAW 264.7 cells in co-culture. Ear skin transplantation of tetrandrine-primed MSCs decreases ear levels of TNF-α in a mouse model of ear skin inflammation. Tetrandrine (1 mg/kg) increases soleus muscle levels of glucose transporter 4 (Glut4) and decreases plasma glucose levels in a rat model of diabetes induced by streptozotocin

Tetrandrine is a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore. Tetrandrine exhibits very broad pharmacological actions, including anti-tumor activity. The beneficial effects of tetrandrine on tumor cell cytotoxicity and radiosensitization, multidrug resistance, normal tissue radioprotection, and angiogenesis are most promising and deserve great attention. Tetrandrine has potential either as a tumoricidal agent or as an adjunct to chemotherapy and radiotherapy.

Details

Tetrandrine is a calcium channel protein inhibitor. Tetrandrine blocks the L-type (IC50= 0.3-8 µM) and T-type (IC50= 2.5-20 µM) calcium channels. It is also a potent blocker of the Ca2+-activated K+ channel (Kd= 0.2 µM).

• Product name

  Tetrandrine, Calcium channel blocker

• Description

  Calcium channel blocker. Anti-inflammatory and antitumor agent.

• Biological description

  Calcium channel blocker. (IC₅₀ values are 8 and 20 µM for L -type and T-type calcium channels respectively). Various pharmacological effects. Shows anti-inflammatory and antitumor activity. Inhibits osteoclast differentiation in vivo. Induces cell autophagy and ROS accumulation. Inhibits NF-κβ signaling.

• Purity

  > 98%

• CAS Number

  518-34-3

• Chemical structure