Keywords

• good producer 25316-40-9
• Hot Sale 25316-40-9
• Doxorubicin hydrochloride in stock

Quick Details

• ProName: good producer 25316-40-9 Hot Sale 2531...
• CasNo: 25316-40-9
• Molecular Formula: C27H29NO11.HCl
• Appearance: white powder
• Application: Doxorubicin hydrochloride (adriamycin ...
• DeliveryTime: 3days
• PackAge: 10g/pack,100g/pack,1kg/pack
• Port: Shanghai port
• ProductionCapacity: 10000 Gram/Month
• Purity: 99%
• Storage: Store in dry、dark、ventilated place.
• Transportation: BY EMS
• LimitNum: 10 Gram
• Related Substances: qualified
• Residue on Ignition: qualified
• Heavy Metal: qualified
• Valid Period: 2years
• Batch: 20170805

Superiority

good producer 25316-40-9 Hot Sale Doxorubicin hydrochloride in stock

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once Doxorubicin hydrochloride associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II). This general mechanism gives Doxorubicin hydrochloride efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin hydrochloride. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR. Doxorubicin hydrochloride is also known as Hydroxydaunorubicin Hydrochloride, DOX, and (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride.

Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.

Details

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic agent that inhibits DNA topoisomerase. It also inhibits nucleic acid synthesis and induces apoptosis. It posses fluorescent property, which enable it for the measurement of drug efflux pump activities and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs.

• Product name

  Doxorubicin hydrochloride, Topoisomerase II inhibitor

• Description

  Topoisomerase II inhibitor. Antibiotic with cytotoxic actions.

• Alternative names

  • Adriamycin

• Purity

  > 98%

• CAS Number

  25316-40-9

• Chemical structure