Keywords

• Hot Sale 171596-29-5
• supplier 171596-29-5
• good producer Tadalafil

Quick Details

• ProName: Hot Sale 171596-29-5 supplier 171596-2...
• CasNo: 171596-29-5
• Molecular Formula: C22H19N3O4
• Appearance: white powder
• Application: Male Sex Hormones
• DeliveryTime: 3days
• PackAge: 10G/pack,100g/pack,1kg/pack (aluminium...
• Port: Shanghai port
• ProductionCapacity: 10000 Kilogram/Year
• Purity: 99%
• Storage: Storage in a dry, ventilated place und...
• Transportation: by EMS,FEDEX,UPS
• LimitNum: 100 Gram
• Related Substances: qualified
• Residue on Ignition: qualified
• Heavy Metal: qualified
• Valid Period: 2years
• Batch: 20210802

Superiority

Hot Sale 171596-29-5 supplier 171596-29-5 good producer Tadalafil

Tadalafil is a potent and highly selective PDE5 inhibitor (IC₅₀ = 5 nM). Exhibits > 2000-fold selectivity for PDE5 over PDEs 1,2,3 and 4 and 1000-fold selectivity over PDE6. Reduces blood pressure in hypertensive rats. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression. Orally bioavailable.

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

Details