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CAS NO.15307-79-6
99%(1-100)Kilogram
top purity 15307-79-6 Hot Sale 15307-79-6 Diclofenac sodium for sale
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 µM, for human COX-1 and COX-2, respectively).It is also an active metabolite of diclofenac methyl ester and diclofenac amide Diclofenac inhibits release of arachidonic acid induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 µM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.
| Catalogue Number | D436450 |
| Chemical Name | Diclofenac Sodium Salt |
| Synonyms | 2-((2,6-Dichlorophenyl)aminobenzeneacetic Acid; [o-(2,6-Dichloroanilino)phenyl]acetic Acid Monosodium Salt; Sodium Diclofenac; Sorelmon; Tsudohmin; Valetan; Voldal; Voltaren; Voltaren Ophtha; Benfofen; Delphimix; Diacron; Naclof; Naclofen; Neriodin; Novapirina; Orthofen; Orthophen;Aceclofenac EP Impurity A |
| Impurity | Aceclofenac EP Impurity A |
| CAS Number | 15307-79-6 |
| Alternate CAS # | Free Acid: 15307-86-5 |
| Molecular Formula | C??H??Cl?NNaO? |
| Appearance | White to Pale Beige Solid |
| Melting Point | >220°C (dec.) |
| Molecular Weight | 318.13 |
| Storage | -20°C Freezer |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | A nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor Aceclofenac EP Impurity A |