Keywords

• factory 113-92-8
• 113-92-8 best quality
• Chlorpheniramine maleate supplier

Quick Details

• ProName: factory 113-92-8 113-92-8 best qualit...
• CasNo: 113-92-8
• Molecular Formula: C20H23ClN2O4
• Appearance: White powder
• Application: The goods antihistamine action over di...
• DeliveryTime: 3days
• PackAge: 1kg/pack,25kg/drum
• Port: Shanghai Port
• ProductionCapacity: 100000 Kilogram/Year
• Purity: 99%min
• Storage: Storage in a dry, ventilated place und...
• Transportation: BY FEDEX
• LimitNum: 1 Kilogram
• Related Substances: qualified
• Residue on Ignition: qualified
• Heavy Metal: qualified
• Valid Period: 2years
• batch: 20210902

Superiority

factory 113-92-8 best quality Chlorpheniramine maleate supplier

Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.

Chlorpheniramine Maleate is a small molecule H₁-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H₁-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H₁-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H₁-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.

Details

Chlorpheniramine is a histamine H₁ receptor antagonist with an IC₇₅ value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD₅₀ = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED_100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

• Product name

  (±)-Chlorpheniramine maleate, H₁ antagonist

• Description

  Potent H₁ antagonist and SNRI

• Biological description

  Potent H₁ antagonist (K_i = 2 nM) and serotonin-norepinephrine reuptake inhibitor (SNRI). Shows antiallergic, antidepressant and antianxiolytic activity.

• Purity

  > 99%

• CAS Number

  113-92-8

• Chemical structure