Keywords

• High Purity 103-90-2
• 103-90-2 in stock
• Acetaminophen superior manufacturer

Quick Details

• ProName: High Purity 103-90-2 103-90-2 in stoc...
• CasNo: 103-90-2
• Molecular Formula: C8H9NO2
• Appearance: White powder
• Application: used in pharmaceuticla
• DeliveryTime: 3-15days
• PackAge: 1kg/pack,25kg/drum
• Port: Shanghai Port
• ProductionCapacity: 10000 Kilogram/Year
• Purity: 99%min
• Storage: Storage in a dry, ventilated place und...
• Transportation: by EMS,FEDEX,UPS
• LimitNum: 1 Kilogram
• Related Substances: qualified
• Residue on Ignition: qualified
• Heavy Metal: qualified
• Valid Period: 2years
• Batch: 20210609

Superiority

High Purity 103-90-2 in stock Acetaminophen superior manufacturer

Acetaminophen differs from the nonsteroidal anti-inflammatory agents described in that itis devoid of anti-inflammatory and antirheumatic properties. It was recently shown thatacetaminophen, like aspirin, inhibits cyclooxygenase action in the brain and is evenstronger than aspirin. On the other hand, the mechanism of analgesic action of acetaminophen is not fully clear, since it acts poorly on peripheral cyclooxygenase.

Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 µM, is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

Administering Acetaminophen (250 mg/kg, orally) to the mice causes significant (p<0.001) liver damage and necrosis of cells as evidenced by the elevated serum hepatic enzymes alanine aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) compared with normal group. Conversely, effects of pretreatment with different doses of citral (125, 250, and 500 mg/kg) exhibited a significant (p<0.05) decrease in serum activities of ALT (91.79%, 93.07%, and 95.61%, resp.), AST (93.40%, 91.89%, and 96.52%, resp.), ALP (39.29%, 37.07%, and 59.80%, resp.), and γGT (92.83%, 91.59%, and 93.0%, resp.), when compared to the Acetaminophen group. Similar results were found in pretreatment with SLM on the activity of ALT (95.90%), AST (95.03%), ALP (70.52%), and γGT (92.69%)

Details