Keywords

• Spironolactone
• 52-01-7
• APIs

Quick Details

• ProName: high-purity Spironolactone 52-01-7 (si...
• CasNo: 52-01-7
• Appearance: white powder
• Application: pharmaceutical
• DeliveryTime: 3days
• PackAge: 10g/pack,100g/pack,1kg/pack
• Port: Shanghai port
• ProductionCapacity: 10000 Kilogram/Year
• Purity: 99%min
• Storage: dry and cool place
• Transportation: by EMS
• LimitNum: 1 Gram

Superiority

1，In No Less five years exporting experience.

2.Lower Price with higher quality

3,Free sample

4,We are sincerely responsible for the "product quality" and "After Service"

Onchem (China) Co.,Ltd  is Specialized in APIs, chemical intermediates, herbal extract and pharmaceutical raw materials.

Details

(1) Company Introduction:

    Onchem (China) Co.,Ltd  is a comprehensive manufacturer and an international distribution of chemicals throughout the 

world. Specialized in APIs, chemical intermediates, herbal extract and pharmaceutical raw materials. our products sell

well in Europe, U.S.A., Japan and Korea, Southeast Asia, Taiwan and other country.

(2) Product Detailed

Name:Spironolactone

Cas No:52-01-7

MF:C₂₄H₃₂O₄S

Use:diuretic agent

Appearance:white powder

 Welcome to Onchem (China) Co.,Ltd, and welcome to inquiry me about all our products, we will provice the 

competitive price for u. We are sincerely responsible for the "product quality" and "After Service"

(3) Application

    It is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist in a class of pharmaceuticals called 

potassium-sparing diuretics, used primarily to treat heart failure, ascites in patients with liver disease, low-renin 

hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and Conn's syndrome 

(primary hyperaldosteronism). On its own, spironolactone is only a weak diuretic because its effects target the distal

nephron (collecting tubule), where urine volume can only be slightly modified; but it can be combined with other diuretics

to increase efficacy. About one person in one hundred with hypertension has elevated levels of aldosterone; in these

persons, the antihypertensive effect of spironolactone may exceed that of complex combined regimens of other

antihypertensives. Due to its antiandrogen effect, it can also be used to treat hirsutism. It is also used for treating hair loss 

and acne in women, and can be used as a topical medication for treatment of male baldness. It is commonly used to treat

symptoms of polycystic ovary syndrome (PCOS) such as excess facial hair and acne. It can also cause gynecomastia in

males and should never be given with potassium supplementation for fear of the development of hyperkalemia.

    Mechanism of action:Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone

receptors in the cortical collecting duct. This decreases the reabsorption of sodium and water, while decreasing the

secretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop, and, so, the effect

diminishes slowly. This is because steroid pathways alter gene transcription, and it will take several days for the gene

products to change (in this case the ENaC and ROMK channels will be decreased). Spironolactone has anti-androgen

activity by binding to the androgen receptorand preventing it from interacting with dihydrotestosterone